Histone Deacetylase 5 Phospho-Ser498 (HDAC5 pS498) Antibody

Catalogue No: abx000254
Price: £230.00
(Size: 50 µl)
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HDAC5 (pS498) Antibody is a Rabbit Polyclonal antibody against HDAC5 (pS498). Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Target Histone Deacetylase 5 Phospho-Ser498 (HDAC5 pS498)
Clonality Polyclonal
Target Modification Ser498
Modification Phosphorylation
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S498 of human HDAC5.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9UQL6 (UniProt, ExPASy)
UniProt Secondary AC C9JFV9, O60340, O60528, Q96DY4
UniProt Entry Name HDAC5_HUMAN
Gene Symbol HDAC5
GeneID 10014
String 9606.ENSP00000225983
Molecular Weight Calculated MW: 112 kDa, 121 kDa, 122 kDa
Observed MW: 140 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Histone Deacetylase 5 Phospho-Ser498 (HDAC5 pS498)

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