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Histone Deacetylase 8 (HDAC8) Antibody
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Catalogue No: abx004469
Price:
US$232.00
(Size: 20 µl)
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![Western blot analysis of lysates from wild type (WT) and HDAC8 knockout (KO) HeLa cells, using [KO Validated] HDAC8 Antibody at 1/1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1/10000 dilution. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Exposure time: 30s.](https://www.abbexa.com/image/cache/data/products/18B/abx004469_1-500x500.jpg "Histone Deacetylase 8 (HDAC8) Antibody")
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HDAC8 Antibody is a Rabbit Polyclonal antibody against HDAC8. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Articles on Histone Deacetylase 8 (HDAC8)
| Target | Histone Deacetylase 8 (HDAC8) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthetic peptide corresponding to HDAC8. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9BY41 (UniProt, ExPASy) |
| UniProt Entry Name | HDAC8_HUMAN |
| Gene Symbol | HDAC8 |
| GeneID | 55869 |
| NCBI Accession | NP_060956.1 |
| String | 9606.ENSP00000362674 |
| Molecular Weight | Calculated MW: 42 kDa Observed MW: 45 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |