Heat Shock 70 kDa Protein 8 (HSC70) Antibody

Heat Shock 70 kDa Protein 8 (HSC70) Antibody is a Mouse Monoclonal antibody for the detection of Hsc70.

HSPA8 (also known as HSC70) is a member of the HSPA (HSP70) family of heat-shock proteins which are highly conserved chaperons implicated in protein folding, protein refolding, protein transport, and protein targeting. HSPA8 is a constitutively expressed cytosol/nuclear protein able to translocate between cytoplasm and nucleus. Recently it has been reported that HSPA8 can interact with α-synuclein, the critical pathological protein of Parkinson's disease, indicating its implication in neurodegenerative disease. (21832061)

Target	Heat Shock 70 kDa Protein 8 (HSC70)
Clonality	Monoclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	WB: 1/3000 - 1/20000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Hsc70
Isotype	IgG1
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P11142 (UniProt, ExPASy)
UniProt Secondary AC	Q9H3R6
Gene Symbol	HSPA8
GeneID	3312
OMIM	600816
HGNC	5241
Ensembl	ENSG00000109971
Molecular Weight	Observed MW: 70 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Heat Shock 70 kDa Protein 8 (HSC70)

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