HER4 (pY1284) Antibody

Catalogue No: abx000119
Price: £120.00
(Size: 20 µl)
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HER4 (pY1284) Antibody is a Rabbit Polyclonal antibody against HER4 (pY1284). This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Target HER4 (pY1284)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y1284 of human HER4.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q15303 (UniProt, ExPASy)
UniProt Secondary AC B7ZLD7, B7ZLE2, B7ZLE3, Q2M1W1, Q59EW4
UniProt Entry Name ERBB4_HUMAN
Gene Symbol ERBB4
GeneID 2066
KEGG hsa:2066
String 9606.ENSP00000342235
Molecular Weight Calculated MW: 143 kDa, 145 kDa, 146 kDa
Observed MW: 200 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on HER4 (pY1284)

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