HER4 (pY1284) Antibody
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Catalogue No: abx000119
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US$232.00
(Size: 20 µl)
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Datasheet SDS
HER4 (pY1284) Antibody is a Rabbit Polyclonal antibody against HER4 (pY1284). This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Research Articles on HER4 (pY1284)
| Target | HER4 (pY1284) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthetic peptide corresponding to HER4 (pY1284). The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q15303 (UniProt, ExPASy) |
| UniProt Secondary AC | B7ZLD7, B7ZLE2, B7ZLE3, Q2M1W1, Q59EW4 |
| UniProt Entry Name | ERBB4_HUMAN |
| Gene Symbol | ERBB4 |
| GeneID | 2066 |
| NCBI Accession | NP_005226.1 |
| KEGG | hsa:2066 |
| String | 9606.ENSP00000342235 |
| Molecular Weight | Calculated MW: 147 kDa Observed MW: 180 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |