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Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody
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Catalogue No: abx004317
Price:
US$348.00
(Size: 60 µl)
Orders to United States ship from United States
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HEXA Antibody is a Rabbit Polyclonal antibody against HEXA. This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
Research Articles on Beta-Hexosaminidase Subunit Alpha (HEXA)
| Target | Beta-Hexosaminidase Subunit Alpha (HEXA) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human HEXA |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P06865 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DKE7, E7ENH7, Q53HS8, Q6AI32 |
| UniProt Entry Name | HEXA_HUMAN |
| Gene Symbol | HEXA |
| GeneID | 3073 |
| NCBI Accession | NP_000511.2 |
| KEGG | hsa:3073 |
| String | 9606.ENSP00000268097 |
| Molecular Weight | Calculated MW: 19 kDa/60 kDa Observed MW: 55 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
