Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody

HEXA Antibody is a Rabbit Polyclonal antibody against HEXA. This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).

Target	Beta-Hexosaminidase Subunit Alpha (HEXA)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 270-529 of human HEXA.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P06865 (UniProt, ExPASy)
UniProt Secondary AC	B4DKE7, E7ENH7, Q53HS8, Q6AI32
UniProt Entry Name	HEXA_HUMAN
Gene Symbol	HEXA
GeneID	3073
NCBI Accession	NP_000511.2
KEGG	hsa:3073
String	9606.ENSP00000268097
Molecular Weight	Calculated MW: 61 kDa Observed MW: 55 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Beta-Hexosaminidase Subunit Alpha (HEXA)

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