Hereditary Hemochromatosis Protein (HFE) Antibody

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M).It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin.The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene.At least nine alternatively spliced variants have been described for this gene.Additional variants have been found but their full-length nature has not been determined.

Target	Hereditary Hemochromatosis Protein (HFE)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human HFE expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q30201 (UniProt, ExPASy)
UniProt Entry Name	HFE_HUMAN
Gene Symbol	HFE
GeneID	3077
OMIM	176200
HGNC	4886
KEGG	hsa:3077
Ensembl	ENSG00000010704
String	9606.ENSP00000417404
Molecular Weight	40 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Hereditary Hemochromatosis Protein (HFE)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue