Histone H2A.x (pS139) Antibody
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Catalogue No: abx000167
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US$232.00
(Size: 20 µl)
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Datasheet SDS
Histone H2A.x (pS139) Antibody is a Rabbit Polyclonal antibody against Histone H2A.x (pS139). Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
Research Articles on Histone H2A.x (pS139)
| Target | Histone H2A.x (pS139) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/100 - 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around S139 of human Histone H2AX. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P16104 (UniProt, ExPASy) |
| UniProt Secondary AC | Q4ZGJ7, Q6IAS5 |
| UniProt Entry Name | H2AX_HUMAN |
| Gene Symbol | H2AFX |
| GeneID | 3014 |
| NCBI Accession | NP_002096.1 |
| KEGG | hsa:3014 |
| String | 9606.ENSP00000434024 |
| Molecular Weight | Calculated MW: 15 kDa Observed MW: 17 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |