Hexokinase 1 (HK1) Antibody

The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate.Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK).Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids.Glucokinase lacks the N-terminal hydrophobic cluster.The hydrophobic cluster is thought to be necessary for membrane binding.This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases.HK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines.

Target	Hexokinase 1 (HK1)
Clonality	Monoclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human HK1 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P19367 (UniProt, ExPASy)
UniProt Entry Name	HXK1_HUMAN
GeneID	3098
KEGG	hsa:3098
String	9606.ENSP00000402103
Molecular Weight	120 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Hexokinase 1 (HK1)

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