Hexokinase 1 (HK1) Antibody

HK1 Antibody is a Rabbit Polyclonal antibody against HK1. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.

Target	Hexokinase 1 (HK1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/200-400 µg whole cell extracts. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 21-219 of human HK1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P19367 (UniProt, ExPASy)
UniProt Entry Name	HXK1_HUMAN
Gene Symbol	HK1
GeneID	3098
NCBI Accession	NP_000179.2
KEGG	hsa:3098
String	9606.ENSP00000402103
Molecular Weight	Calculated MW: 102 kDa Observed MW: 102 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	1.21 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Hexokinase 1 (HK1)

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