HLA class I histocompatibility antigen, C alpha chain (HLA-C) Antibody
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Catalogue No: abx029839
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US$326.25
(Size: 80 µl)
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Datasheet SDS
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.
Research Articles on HLA class I histocompatibility antigen, C alpha chain (HLA-C)
| Target | HLA class I histocompatibility antigen, C alpha chain (HLA-C) |
| Research Area | Immunology |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 66-93 amino acids from the Central region of human HLA-C. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P10321 (UniProt, ExPASy) |
| UniProt Secondary AC | O02863, O02864, O02865, O02866, O02958, O19505, O19652, O19676, O62879, O62882, O62883, O62888, O78060, O78061, O78062, O78063, O78067, O78068, O78069, O78072, O78083, O78090, O78091, O78149, O78165, O78166, O78178, O78202, O78203, O78211, O78214, P04222, P30499, P30500, P30501, P30502, P30503, P30504, P30505, P30506, P30507, P30508, P30509, P30510, P79498, Q07000, Q29631, Q29641, Q29643, Q29652, Q29743, Q29768, Q29862, Q29864, Q29865, Q29867, Q29921, Q29959, Q29960, Q29963, Q29986, Q29989, Q29990, Q29991, Q29992, Q29993, Q30192, Q31605, Q31627, Q860R1, Q860R2, Q95463, Q95603, Q95604, Q99528, Q9BD28, Q9GIK4, Q9GIK8, Q9GJ33, Q9MY30, Q9MY31, Q9MY35, Q9MY49, Q9MY74, Q9MYI3, Q9TNN7, Q9TNZ8, Q9TPS4, Q9TPV8, Q9TPX2, Q9TQB4, Q9TQJ5, Q9TQP9, Q9UM32, Q9UM33, Q9UM42, Q9UQS9 |
| Molecular Weight | Calculated MW: 40.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |