HLA Class II Histocompatibility Antigen, DP Beta 1 Chain (HLA-DPB1) Antibody

HLA-DPB1 Antibody is a Rabbit Polyclonal antibody against HLA-DPB1. HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Target	HLA Class II Histocompatibility Antigen, DP Beta 1 Chain (HLA-DPB1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 30-225 of human HLA-DPB1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P04440 (UniProt, ExPASy)
UniProt Entry Name	DPB1_HUMAN
Gene Symbol	HLA-DPB1
GeneID	3115
NCBI Accession	NP_002112.3
KEGG	hsa:3115
String	9606.ENSP00000408146
Molecular Weight	Calculated MW: 29 kDa Observed MW: 25-35 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on HLA Class II Histocompatibility Antigen, DP Beta 1 Chain (HLA-DPB1)

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