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HLA Class II Histocompatibility Antigen, DP Beta 1 Chain (HLA-DPB1) Antibody

Catalogue No: abx001225
Price: £120.00
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HLA Class II Histocompatibility Antigen, DP Beta 1 Chain (HLA-DPB1) Antibody HLA Class II Histocompatibility Antigen, DP Beta 1 Chain (HLA-DPB1) Antibody

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HLA-DPB1 Antibody is a Rabbit Polyclonal antibody against HLA-DPB1. HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Target HLA-DPB1
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human HLA-DPB1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P04440 (UniProt, ExPASy)
UniProt Entry Name DPB1_HUMAN
Gene Symbol HLA-DPB1
GeneID 3115
KEGG hsa:311
String 9606.ENSP00000408146
Molecular Weight Calculated MW: 29 kDa
Observed MW: 29 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on HLA Class II Histocompatibility Antigen, DP Beta 1 Chain (HLA-DPB1) Antibody

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