HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain (HLA-DQA1) Antibody

HLA-DQA1 Antibody is a Rabbit Polyclonal antibody against HLA-DQA1. HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Target	HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain (HLA-DQA1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 24-216 of human HLA-DQA1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01909 (UniProt, ExPASy)
UniProt Entry Name	DQA1_HUMAN
Gene Symbol	HLA-DQA1
GeneID	3117
NCBI Accession	NP_002113.2
KEGG	hsa:3117
Molecular Weight	Calculated MW: 28 kDa Observed MW: 28 kDaa-37 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain (HLA-DQA1)

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