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Major Histocompatibility Complex, Class II, DR Beta 3 (HLA-DRB3) Antibody

Catalogue No: abx001355
Price: £120.00
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Major Histocompatibility Complex, Class II, DR Beta 3 (HLA-DRB3) Antibody

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HLA-DRB3 Antibody is a Rabbit Polyclonal antibody against HLA-DRB3. HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].

Target HLA-DRB3
Clonality Polyclonal
Reactivity Human, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human HLA-DRB3.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P79483 (UniProt, ExPASy)
UniProt Entry Name DRB3_HUMAN
Gene Symbol HLA-DRB3
GeneID 3125
KEGG hsa:3125
Molecular Weight Calculated MW: 29 kDa
Observed MW: 30 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Major Histocompatibility Complex, Class II, DR Beta 3 (HLA-DRB3) Antibody

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