Porphobilinogen Deaminase (HMBS) Antibody

HMBS Antibody is a Rabbit Polyclonal antibody against HMBS. This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

Target	Porphobilinogen Deaminase (HMBS)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human HMBS.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08397 (UniProt, ExPASy)
UniProt Secondary AC	A8K2L0, G3V1P4, G5EA58, P08396, Q16012
UniProt Entry Name	HEM3_HUMAN
Gene Symbol	HMBS
GeneID	3145
NCBI Accession	NP_000181.2
KEGG	hsa:3145
String	9606.ENSP00000278715
Molecular Weight	Calculated MW: 39 kDa Observed MW: 45 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Porphobilinogen Deaminase (HMBS)

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