High Mobility Group Protein HMGI-C (HMGA2) Antibody

HMGA2 Antibody is a Rabbit Polyclonal antibody against HMGA2. This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Target	High Mobility Group Protein HMGI-C (HMGA2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 55-109 of human HMGA2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P52926 (UniProt, ExPASy)
UniProt Secondary AC	E7EP85, E7EWA2, Q1M182, Q1M185, Q1M186, Q1M187, Q1M188
UniProt Entry Name	HMGA2_HUMAN
Gene Symbol	HMGA2
GeneID	8091
NCBI Accession	NP_003474.1
KEGG	hsa:8091
String	9606.ENSP00000437621
Molecular Weight	Calculated MW: 12 kDa Observed MW: 18 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on High Mobility Group Protein HMGI-C (HMGA2)

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