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3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody

Catalogue No: abx001376
Price: £120.00
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3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody

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HMGCR Antibody is a Rabbit Polyclonal antibody against HMGCR. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

Target HMGCR
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/1000 - 1/4000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human HMGCR.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P04035 (UniProt, ExPASy)
UniProt Secondary AC B7Z3Y9, Q8N190
UniProt Entry Name HMDH_HUMAN
Gene Symbol HMGCR
GeneID 3156
KEGG hsa:3156
String 9606.ENSP00000287936
Molecular Weight Calculated MW: 92 kDa, 97 kDa, 99 kDa
Observed MW: 110 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody

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