Histamine N-Methyltransferase (HNMT) Antibody

In mammals, histamine is metabolized by two major pathways: N (tau) methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N (tau) methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.

Target	Histamine N-Methyltransferase (HNMT)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 29-58 amino acids from the N-terminal region of human HNMT.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P50135 (UniProt, ExPASy)
UniProt Secondary AC	B2R9J3, Q546Z6, Q7Z7I2, Q8IU56, Q8WW98, Q9BRW6
UniProt Entry Name	HNMT_HUMAN
KEGG	hsa:3176
String	9606.ENSP00000280097
Molecular Weight	Calculated MW: 33.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Histamine N-Methyltransferase (HNMT)

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