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Heterogeneous Nuclear Ribonucleoprotein U (HNRNPU) Antibody

Catalogue No: abx002858
Price: £120.00
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Heterogeneous Nuclear Ribonucleoprotein U (HNRNPU) Antibody Heterogeneous Nuclear Ribonucleoprotein U (HNRNPU) Antibody

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HNRNPU Antibody is a Rabbit Polyclonal antibody against HNRNPU. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.

Target HNRNPU
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 608-825 of human HNRNPU.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q00839 (UniProt, ExPASy)
UniProt Secondary AC O75507, Q8N174, Q96HY9, Q9BQ09
UniProt Entry Name HNRPU_HUMAN
Gene Symbol HNRNPU
GeneID 3192
NCBI Accession NP_114032.2
KEGG hsa:3192
String 9606.ENSP00000283179
Molecular Weight Calculated MW: 88 kDa, 90 kDa
Observed MW: 120 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Heterogeneous Nuclear Ribonucleoprotein U (HNRNPU) Antibody

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