Haptoglobin / Zonulin Proprotein (HP) Antibody

Haptoglobin / Zonulin Proprotein (HP) Antibody is a Rabbit Polyclonal antibody against Haptoglobin / Zonulin Proprotein (HP). This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Target	Haptoglobin / Zonulin Proprotein (HP)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Haptoglobin (HP).
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P00738 (UniProt, ExPASy)
UniProt Entry Name	HPT_HUMAN
Gene Symbol	HP
GeneID	3240
NCBI Accession	NP_005134.1
KEGG	hsa:3240
String	9606.ENSP00000348170
Molecular Weight	Calculated MW: 45 kDa Observed MW: 45 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	0.55 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Haptoglobin / Zonulin Proprotein (HP)

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