GTPase HRas (HRAS) Antibody

HRAS belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. These proteins function in signal transduction pathways. They can bind GTP and GDP, and they have intrinsic GTPase activity. HRAS undergoes a continuous cycle of de and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in the HRAS gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma.

Target	GTPase HRas (HRAS)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 104-128 amino acids from the Central region of human HRAS.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01112 (UniProt, ExPASy)
UniProt Secondary AC	B5BUA0, Q14080, Q6FHV9, Q9BR65, Q9UCE2
UniProt Entry Name	RASH_HUMAN
Gene Symbol	HRAS
GeneID	3265
OMIM	109800
NCBI Accession	NP_001123914.1 NP_005334.1 NP_789765.1
KEGG	hsa:3265
Ensembl	ENSG00000174775
String	9606.ENSP00000407586
Molecular Weight	Calculated MW: 21.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat HRAS.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on GTPase HRas (HRAS)

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