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GTPase HRas (HRAS) Antibody
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Catalogue No: abx033667
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US$326.25
(Size: 80 µl)
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Datasheet SDS
HRAS belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. These proteins function in signal transduction pathways. They can bind GTP and GDP, and they have intrinsic GTPase activity. HRAS undergoes a continuous cycle of de and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in the HRAS gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma.
Research Articles on GTPase HRas (HRAS)
| Target | GTPase HRas (HRAS) |
| Research Area | Signal Transduction, Apoptosis, Tumor Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 104-128 amino acids from the Central region of human HRAS. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P01112 (UniProt, ExPASy) |
| UniProt Secondary AC | B5BUA0, Q14080, Q6FHV9, Q9BR65, Q9UCE2 |
| UniProt Entry Name | RASH_HUMAN |
| Gene Symbol | HRAS |
| GeneID | 3265 |
| OMIM | 109800 |
| NCBI Accession | NP_001123914.1 NP_005334.1 NP_789765.1 |
| KEGG | hsa:3265 |
| Ensembl | ENSG00000174775 |
| String | 9606.ENSP00000407586 |
| Molecular Weight | Calculated MW: 21.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat HRAS. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |