11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11B1) Antibody

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Catalogue No: abx001363
Price: US$217.50
(Size: 20 µl)

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Western blot analysis of lysates from mouse liver, using HSD11B1 Antibody at 1/1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1/10000 dilution. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Exposure time: 90S.
11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11B1) Antibody

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Datasheet SDS
HSD11B1 Antibody is a Rabbit Polyclonal antibody against HSD11B1. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Target 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11B1)
Research Area Enzymes and Kinases, Metabolism, Endocrinology, Cardiovascular Biology, Neuroscience, Hepatology, Hormone Metabolism
Clonality Polyclonal
Reactivity Mouse
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein corresponding to HSD11B1. The exact sequence is proprietary.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Shelf Life 12 months.
UniProt Primary AC P28845 (UniProt, ExPASy)
UniProt Secondary AC B2R9Z1, D3DT89
UniProt Entry Name DHI1_HUMAN
Gene Symbol HSD11B1
GeneID 3290
NCBI Accession NP_005516.1
KEGG hsa:3290
String 9606.ENSP00000355995
Molecular Weight Calculated MW: 32 kDa
Observed MW: 32 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11B1)


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