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11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11B1) Antibody

Catalogue No: abx001363
Price: £120.00
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11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11B1) Antibody

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HSD11B1 Antibody is a Rabbit Polyclonal antibody against HSD11B1. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Target HSD11B1
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human HSD11B1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P28845 (UniProt, ExPASy)
UniProt Secondary AC B2R9Z1, D3DT89
UniProt Entry Name DHI1_HUMAN
Gene Symbol HSD11B1
GeneID 3290
KEGG hsa:3290
String 9606.ENSP00000355995
Molecular Weight Calculated MW: 32 kDa
Observed MW: 32 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11B1) Antibody

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