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Heat Shock Protein 90 Alpha (HSP90A) Antibody (Biotin)
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Catalogue No: abx442819
Price:
US$783.00
(Size: 200 µg)
Orders to United States ship from United States
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Heat Shock Protein 90 Alpha (HSP90A) Antibody is a Mouse monoclonal against Heat Shock Protein 90 Alpha (HSP90A). HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex. Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (1–2% of cytosolic protein). It carries out a number of housekeeping functions – including controlling the activity, turnover, and trafficking of a variety of proteins, and it's target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase. When bound to ATP, HSP90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. Variations in HSP90 expression or HSP90 mutation has been shown to degrade signaling function or impair it's function. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit HSP90 function.
Research Articles on Heat Shock Protein 90 Alpha (HSP90A)
| Target | Heat Shock Protein 90 Alpha (HSP90A) |
| Research Area | Cancer, Heat Shock, Cell Signalling, Protein Trafficking, Chaperone Proteins, Tumor Biomarkers |
| Clonality | Monoclonal |
| Clone | V861 |
| Reactivity | Human, Mouse, Rat, Rabbit, Chicken, Plant, Fungus, Insect |
| Tested Applications | WB, IHC |
| Host | Mouse |
| Recommended dilutions | WB: 1/1000, IHC: 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Biotin |
| Immunogen | Heat Shock Protein 90 from the water mold Achyla ambisexualis. |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Purified by Protein G. |
| Storage | Aliquot and store at 4°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q8LLI5 (UniProt, ExPASy) |
| GeneID | 4768 |
| NCBI Accession | AAM90675.1 |
| Buffer | 136.36 mM Ethanolamine, 133.23 mM Chlorides, 9.55 mM Phosphates, 9.55 mM Sodium Bicarbonate. |
| Specificity | Detects 90kDa. This antibody is reactive with both the constitutive and the inducible form of HSP90. It does not bind to the native form and does not recognize HSP90 from E.coli or yeast. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |