Heat Shock 70 kDa Protein 5 (HSPA5) Antibody

When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.

Target	Heat Shock 70 kDa Protein 5 (HSPA5)
Clonality	Polyclonal
Reactivity	Human, Zebrafish
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 261-289 amino acids from the Central region of human HSPA5.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P11021 (UniProt, ExPASy)
UniProt Secondary AC	B0QZ61, Q2EF78, Q9NPF1, Q9UK02
UniProt Entry Name	BIP_HUMAN
KEGG	hsa:3309
String	9606.ENSP00000324173
Molecular Weight	Calculated MW: 72.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow, Chicken and Hamster HSPA5.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Heat Shock 70 kDa Protein 5 (HSPA5)

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