BRISC And BRCA1-A Complex Member 1 (HSPC142) Antibody
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Catalogue No: abx034003
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US$326.25
(Size: 80 µl)
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Datasheet SDS
HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
Research Articles on BRISC And BRCA1-A Complex Member 1 (HSPC142)
| Target | BRISC And BRCA1-A Complex Member 1 (HSPC142) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9NWV8 (UniProt, ExPASy) |
| UniProt Secondary AC | A8MQT0, B4DRY9, B4DVR1, Q6FIA0, Q9P018 |
| UniProt Entry Name | BABA1_HUMAN |
| Gene Symbol | BABAM1 |
| String | 9606.ENSP00000352408 |
| Molecular Weight | Calculated MW: 36.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Cow and Zebrafish BABAM1. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |