Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Protein

Catalogue No: abx650811
Price: £160.00
(Size: 10 µg)
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Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Protein is a recombinant Human protein produced in E. coli using Prokaryotic expression. This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Target Lys-63-Specific Deubiquitinase BRCC36 (BRCC3)
Origin Human
Expression Recombinant
Tested Applications WB, SDS-PAGE
Host E. coli
Conjugation Unconjugated
Form Lyophilized
Purity > 95%
Reconstitution Reconstitute to the original concentration in ddH2O. If further dilutions are required, dilute in PBS, pH 7.4, to a concentration of 0.1-1.0 mg/ml. Do not vortex.
Storage Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P46736 (UniProt, ExPASy)
UniProt Secondary AC A6QRF8, A6QRF9, A8MUX5, A8MWH0, A9Z1Y0, A9Z1Y5, B1B062, B4DQN7, Q16107, Q53YX5, Q9BTZ6
UniProt Entry Name BRCC3_HUMAN
Gene Symbol BRCC3
GeneID 79184
OMIM 300617
NCBI Accession NP_001018065.1 NM_001018055.2 NP_001229569.1 NM_001242640.1 NP_077308.1 NM_024332.3
HGNC 24185
KEGG hsa:79184
Ensembl ENSG00000185515
String 9606.ENSP00000358474
Molecular Weight Calculated MW: 19.8 kDa
Sequence Fragment Gln7-Gly148
Tag N-terminal His tag
Buffer Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Activity Not tested
Concentration Prior to lyophilization: 200 µg/ml
Availability Shipped within 5-7 working days.
Note This product is for research use only.

Not for human consumption, cosmetic, therapeutic or diagnostic use.
Research Articles on Lys-63-Specific Deubiquitinase BRCC36 (BRCC3)

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