Human Neurofilament, Light Polypeptide (NEFL) CLIA Kit

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Catalogue No: abx494482
Price: US$942.50
(Size: 96 tests)

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Human Neurofilament, Light Polypeptide (NEFL) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates, cerebrospinal fluid, cell culture supernates and other biological fluids.

Introduction Neurofilament Light Polypeptide (NEFL) is one of five proteins that commonly form filaments in neuronal cells, with the other four being Neurofilament Medium and Heavy Polypeptide, as well as either peripherin or internexin. Together, these form neurofilaments, which form part of the neuronal cytoskeleton. NEFL and NEFM are found in close proximity to each other on human chromosome 8 and share some homology, suggesting that one could be the product of an ancestral gene duplication of the other. NEFL found in plasma or cerebrospinal fluid is used as a biomarker of nerve damage in multiple sclerosis and Alzheimer’s. Mutations in NEFL are associated with Charcot-Marie-Tooth disease.
Target Neurofilament, Light Polypeptide (NEFL)
Reactivity Human
Tested Applications CLIA
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Storage Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Validity The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
Stability The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.
Test Range 1.37 pg/ml - 1000 pg/ml
Sensitivity < 0.63 pg/ml
Standard Form Lyophilized
Detection Method Chemiluminescent
Assay Type Sandwich
Assay Data Quantitative
Sample Type Serum, plasma, tissue homogenates, cell lysates, cerebrospinal fluid, cell culture supernatants and other biological fluids.
Availability Shipped within 5-20 working days.
Note This product is for research use only.

The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.

Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Standard 1000 pg/ml
Research Articles on Neurofilament, Light Polypeptide (NEFL)


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