Human Parathyroid Hormone-Related Protein / PTHrP (PTHLH) CLIA Kit
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Catalogue No: abx490252
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US$942.50
(Size: 96 tests)
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Human Parathyroid Hormone Related Protein (PTHrP/PTHLH/PLP) Chemiluminescent Immunoassay (CLIA) Kit is a Competitive Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Research Articles on Parathyroid Hormone-Related Protein / PTHrP (PTHLH)
| Introduction | Parathyroid Hormone-Related Protein (PTHrP) is a member of the parathyroid hormone family, which in humans includes this protein and Parathyroid Hormone (PTH). PTHrP is responsible for regulating bone metabolism and mammary gland development. In the jaw, it causes localised resorption of bone before the teeth are pushed into the oral cavity, while in the breast it stimulates epithelial-mesenchymal transition to form and maintain the mammary glands. PTHrP is overexpressed in some cancers, where it leads to hypercalcemia. Mutations in its gene are associated with type E brachydactyly. |
| Target | Parathyroid Hormone-Related Protein / PTHrP (PTHLH) |
| Research Area | Tumor Immunity, Endocrinology, Hormone Metabolism, Bone Metabolism, Cancer |
| Reactivity | Human |
| Tested Applications | CLIA |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Shelf Life | Up to 12 months. |
| Stability | The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
| UniProt Primary AC | P12272 (UniProt, ExPASy) |
| UniProt Secondary AC | Q15251, Q6FH74 |
| UniProt Entry Name | PTHR_HUMAN |
| Gene Symbol | PTHLH |
| GeneID | 5744 |
| OMIM | 168470 |
| HGNC | 9607 |
| KEGG | hsa:5744 |
| Ensembl | ENSG00000087494 |
| Test Range | 12.35 pg/ml - 1000 pg/ml |
| Sensitivity | < 4.94 pg/ml |
| Standard Form | Lyophilized |
| Detection Method | Chemiluminescent |
| Assay Type | Competitive |
| Assay Data | Quantitative |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
| Standard | 1000 pg/ml |
