Human Troponin T, Cardiac Muscle (TNNT2) Protein
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Catalogue No: abx069499
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(Size: 10 µg)
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Datasheet SDS
Human Troponin T, Cardiac Muscle (TNNT2) is a recombinant Human protein expressed in E. coli. The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.
Research Articles on Troponin T, Cardiac Muscle (TNNT2)
| Target | Troponin T, Cardiac Muscle (TNNT2) |
| Research Area | Cardiovascular Biology |
| Origin | Human |
| Expression | Recombinant |
| Tested Applications | WB, SDS-PAGE |
| Host | E. coli |
| Conjugation | Unconjugated |
| Form | Lyophilized |
| Activity | Not tested |
| Purity | > 95% |
| Reconstitution | To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P45379 (UniProt, ExPASy) |
| UniProt Secondary AC | A2TDB9, A8K3K6, O60214, Q99596, Q99597, Q9BUF6, Q9UM96 |
| UniProt Entry Name | TNNT2_HUMAN |
| Gene Symbol | TNNT2 |
| GeneID | 7139 |
| OMIM | 115195 |
| NCBI Accession | NP_001001432.1 NM_001001432.2 |
| HGNC | 11949 |
| Ensembl | ENSG00000118194 |
| String | 9606.ENSP00000236918 |
| Molecular Weight | Calculated MW: 41.5 kDa Observed MW (SDS-PAGE): 55 kDa |
| Sequence Fragment | Ser2-Ile100 |
| Sequence | SDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI |
| Tag | N-terminal His tag and GST tag |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Concentration | Prior to lyophilization: 200 µg/ml |
| Availability | Shipped within 5-7 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |