Islet Amyloid Polypeptide (IAPP) Antibody

IAPP Antibody is a Rabbit Polyclonal antibody against IAPP. Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

Target	Islet Amyloid Polypeptide (IAPP)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-89 of human IAPP.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10997 (UniProt, ExPASy)
UniProt Secondary AC	Q0ZD87, Q14598
UniProt Entry Name	IAPP_HUMAN
Gene Symbol	IAPP
GeneID	3375
NCBI Accession	NP_000406.1
KEGG	hsa:3375
String	9606.ENSP00000240652
Molecular Weight	Calculated MW: 10 kDa Observed MW: 35 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Islet Amyloid Polypeptide (IAPP)

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