Islet Amyloid Polypeptide (IAPP) Antibody
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Catalogue No: abx002102
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US$217.50
(Size: 20 µl)
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Datasheet SDS
IAPP Antibody is a Rabbit Polyclonal antibody against IAPP. Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
Research Articles on Islet Amyloid Polypeptide (IAPP)
| Target | Islet Amyloid Polypeptide (IAPP) |
| Research Area | Neuroscience, Neuropeptides |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1-89 of human IAPP. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P10997 (UniProt, ExPASy) |
| UniProt Secondary AC | Q0ZD87, Q14598 |
| UniProt Entry Name | IAPP_HUMAN |
| Gene Symbol | IAPP |
| GeneID | 3375 |
| NCBI Accession | NP_000406.1 |
| KEGG | hsa:3375 |
| String | 9606.ENSP00000240652 |
| Molecular Weight | Calculated MW: 10 kDa Observed MW: 35 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |