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Insulin Degrading Enzyme (IDE) Antibody

Catalogue No: abx001373
Price: £160.00
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Insulin Degrading Enzyme (IDE) Antibody Insulin Degrading Enzyme (IDE) Antibody Insulin Degrading Enzyme (IDE) Antibody

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IDE Antibody is a Rabbit Polyclonal antibody against IDE. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].

Target IDE
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human IDE.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P14735 (UniProt, ExPASy)
UniProt Secondary AC B2R721, B7ZAU2, D3DR35, Q5T5N2
UniProt Entry Name IDE_HUMAN
Gene Symbol IDE
GeneID 3416
KEGG hsa:3416
String 9606.ENSP00000265986
Molecular Weight Calculated MW: 54 kDa, 117 kDa
Observed MW: 105 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Insulin Degrading Enzyme (IDE) Antibody

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