Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1) Antibody

REQUEST MORE INFO
Catalogue No: abx001781
Price: US$203.00
(Size: 20 µl)

Click on the image to see the image legend

Available Options

* Size:




Add to Shopping Cart Buy It Now GET A QUOTE

Documents

Datasheet SDS
IDH1 Antibody is a Rabbit Polyclonal antibody against IDH1. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Target Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1)
Clonality Polyclonal
Reactivity Human, Mouse, Rat, Monkey
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human IDH1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O75874 (UniProt, ExPASy)
UniProt Secondary AC Q567U4, Q6FHQ6, Q7Z3V0, Q93090, Q9NTJ9, Q9UKW8
UniProt Entry Name IDHC_HUMAN
Gene Symbol IDH1
GeneID 3417
NCBI Accession NP_005887.2
KEGG hsa:3417
String 9606.ENSP00000390265
Molecular Weight Calculated MW: 47 kDa
Observed MW: 46 kDa
Buffer PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1)


Write a review

Tags:
(Click to show)