Interferon Gamma (IFNG) Antibody

Interferon gamma (IFN gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN gamma strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon gamma through the activation of transcription factor NFKB.

Target	Interferon Gamma (IFNG)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human IFN-gamma expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01579 (UniProt, ExPASy)
UniProt Secondary AC	B5BU88, Q53ZV4
UniProt Entry Name	IFNG_HUMAN
Gene Symbol	IFNG
GeneID	3458
OMIM	147570
HGNC	5438
KEGG	hsa:3458
Ensembl	ENSG00000111537
String	9606.ENSP00000229135
Molecular Weight	19 kDa
Buffer	PBS, containing 0.03% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Interferon Gamma (IFNG)

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