Interferon Gamma (IFNG) Antibody

IFN-gamma (interferon, gamma) is an antiviral and antiparasitic agent produced by CD4+/CD8+ lymphocytes and natural killer cells that undergo activation by antigens, mitogens or alloantigens.It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses, including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts.The active form of IFN-G is a homodimer with each subunit containing six helices.The dimeric structure of human IFN-G is stabilized by non-covalent interactions through the interface of the helices.IFN-G translated precursor is 166 amino acids, including the 23 amino acid secretory sequence.It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN.Multiple forms exist due to variable glycosylation and under non-denaturing conditions due to dimers and tetramers.

Target	Interferon Gamma (IFNG)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant human IFN-gamma (BioSource company, Cat.No.PHC4033).
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01579 (UniProt, ExPASy)
UniProt Secondary AC	B5BU88, Q53ZV4
UniProt Entry Name	IFNG_HUMAN
Gene Symbol	IFNG
GeneID	3458
OMIM	147570
HGNC	5438
KEGG	hsa:3458
Ensembl	ENSG00000111537
String	9606.ENSP00000229135
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Interferon Gamma (IFNG)

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