Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody
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Catalogue No: abx010963
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US$427.75
(Size: 100 µl)
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Datasheet SDS
IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
Research Articles on Insulin Like Growth Factor 1 Receptor (IGF1R)
| Target | Insulin Like Growth Factor 1 Receptor (IGF1R) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of IGF1R-Beta expressed in E. coli. |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P08069 (UniProt, ExPASy) |
| UniProt Secondary AC | B1B5Y2, Q14CV2, Q9UCC0 |
| UniProt Entry Name | IGF1R_HUMAN |
| Gene Symbol | IGF1R |
| GeneID | 3480 |
| OMIM | 147370 |
| HGNC | 5465 |
| KEGG | hsa:3480 |
| Ensembl | ENSG00000140443 |
| String | 9606.ENSP00000268035 |
| Molecular Weight | 96 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |