Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta / IKKB (IKBKB) Antibody

IKBKB (Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP.Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination.IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta.Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1.Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response.Additionally, IKK-beta activity can also be regulated by MEKK-1.

Target	Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta / IKKB (IKBKB)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of IKBKB expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14920 (UniProt, ExPASy)
UniProt Secondary AC	B4DZ30, B4E0U4, O75327
UniProt Entry Name	IKKB_HUMAN
Gene Symbol	IKBKB
GeneID	3551
OMIM	603258
HGNC	5960
KEGG	hsa:3551
Ensembl	ENSG00000104365
String	9606.ENSP00000430684
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta / IKKB (IKBKB)

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