Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta / IKKB (IKBKB) Antibody
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Catalogue No: abx016029
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(Size: 100 µl)
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Datasheet SDS
IKBKB (Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP.Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination.IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta.Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1.Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response.Additionally, IKK-beta activity can also be regulated by MEKK-1.
Research Articles on Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta / IKKB (IKBKB)
| Target | Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta / IKKB (IKBKB) |
| Research Area | Enzymes and Kinases |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of IKBKB expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O14920 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DZ30, B4E0U4, O75327 |
| UniProt Entry Name | IKKB_HUMAN |
| Gene Symbol | IKBKB |
| GeneID | 3551 |
| OMIM | 603258 |
| HGNC | 5960 |
| KEGG | hsa:3551 |
| Ensembl | ENSG00000104365 |
| String | 9606.ENSP00000430684 |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |