IKAROS Family Zinc Finger 1 (IKZF1) Antibody

Catalogue No: abx001530
Price: £120.00
(Size: 20 µl)
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IKAROS Family Zinc Finger 1 (IKZF1) Antibody IKAROS Family Zinc Finger 1 (IKZF1) Antibody

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IKZF1 Antibody is a Rabbit Polyclonal antibody against IKZF1. This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Target IKZF1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human IKZF1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q13422 (UniProt, ExPASy)
UniProt Secondary AC A4D260, B4E0Z1, D3DVM5, O00598, Q53XL2, Q69BM4, Q8WVA3
UniProt Entry Name IKZF1_HUMAN
Gene Symbol IKZF1
GeneID 10320
KEGG hsa:10320
String 9606.ENSP00000331614
Molecular Weight Calculated MW: 24-31 kDa, 41-57 kDa
Observed MW: 46 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on IKAROS Family Zinc Finger 1 (IKZF1) Antibody

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