Interleukin 10 (IL10) Antibody

The protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

Target	Interleukin 10 (IL10)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 27-53 amino acids from the Central region of human IL10.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P22301 (UniProt, ExPASy)
UniProt Entry Name	IL10_HUMAN
Gene Symbol	IL10
KEGG	hsa:3586
String	9606.ENSP00000412237
Molecular Weight	Calculated MW: 20.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey and Epstein Barr Virus (EBV) IL10.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Interleukin 10 (IL10)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue