Interleukin 10 (IL10) Antibody

Catalogue No: abx001783
Price: £120.00
(Size: 20 µl)
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IL10 Antibody is a Rabbit Polyclonal antibody against IL10. The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Target IL10
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 19-178 of human IL10.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P22301 (UniProt, ExPASy)
UniProt Entry Name IL10_HUMAN
Gene Symbol IL10
GeneID 3586
KEGG hsa:3586
String 9606.ENSP00000412237
Molecular Weight Calculated MW: 20 kDa
Observed MW: 22 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 2.89 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on IL10

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