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Interleukin 12 Receptor Beta 1 (IL12RB1) Antibody
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Catalogue No: abx001549
Price:
US$217.50
(Size: 20 µl)
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IL12RB1 Antibody is a Rabbit Polyclonal antibody against IL12RB1. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
Research Articles on Interleukin 12 Receptor Beta 1 (IL12RB1)
| Target | Interleukin 12 Receptor Beta 1 (IL12RB1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to IL12RB1. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P42701 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K308, B2RPF1, B7ZKK3, Q8N6Q7 |
| UniProt Entry Name | I12R1_HUMAN |
| Gene Symbol | IL12RB1 |
| GeneID | 3594 |
| NCBI Accession | NP_714912.1 |
| KEGG | hsa:3594 |
| String | 9606.ENSP00000470788 |
| Molecular Weight | Calculated MW: 73 kDa Observed MW: 102 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |