Interleukin 12 Receptor Beta 1 (IL12RB1) Antibody

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Catalogue No: abx001549
Price: US$203.00
(Size: 20 µl)

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Datasheet SDS
IL12RB1 Antibody is a Rabbit Polyclonal antibody against IL12RB1. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

Target Interleukin 12 Receptor Beta 1 (IL12RB1)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 25-305 of human IL12RB1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P42701 (UniProt, ExPASy)
UniProt Secondary AC A8K308, B2RPF1, B7ZKK3, Q8N6Q7
UniProt Entry Name I12R1_HUMAN
Gene Symbol IL12RB1
GeneID 3594
NCBI Accession NP_714912.1
KEGG hsa:3594
String 9606.ENSP00000470788
Molecular Weight Calculated MW: 73 kDa
Observed MW: 102 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Interleukin 12 Receptor Beta 1 (IL12RB1)


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