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Interleukin 12 Receptor Beta 1 (IL12RB1) Antibody

Catalogue No: abx001549
Price: £120.00
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Interleukin 12 Receptor Beta 1 (IL12RB1) Antibody Interleukin 12 Receptor Beta 1 (IL12RB1) Antibody

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IL12RB1 Antibody is a Rabbit Polyclonal antibody against IL12RB1. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

Target IL12RB1
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human IL12RB1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P42701 (UniProt, ExPASy)
UniProt Secondary AC A8K308, B2RPF1, B7ZKK3, Q8N6Q7
UniProt Entry Name I12R1_HUMAN
Gene Symbol IL12RB1
GeneID 3594
KEGG hsa:3594
String 9606.ENSP00000470788
Molecular Weight Calculated MW: 42 kDa, 72 kDa, 73 kDa
Observed MW: 73 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Interleukin 12 Receptor Beta 1 (IL12RB1) Antibody

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