Interleukin 6 Receptor (IL6R) Antibody

IL6R Antibody is a Rabbit Polyclonal antibody against IL6R. Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL6R, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL6R, the complex of IL-6 and IL6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892). Soluble form of IL6R has been found in human serum and urine.

Target	Interleukin 6 Receptor (IL6R)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 20-365 of human IL6R.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08887 (UniProt, ExPASy)
UniProt Secondary AC	A8KAE8, B2R6V4, Q16202, Q53EQ7, Q5FWG2, Q5VZ23
UniProt Entry Name	IL6RA_HUMAN
Gene Symbol	IL6R
GeneID	3570
NCBI Accession	NP_000556.1
KEGG	hsa:3570
String	9606.ENSP00000357470
Molecular Weight	Calculated MW: 52 kDa Observed MW: 70-100 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Interleukin 6 Receptor (IL6R)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue