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Interleukin 6 Receptor (IL6R) Antibody

Catalogue No: abx001321
Price: £120.00
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Interleukin 6 Receptor (IL6R) Antibody

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IL6R Antibody is a Rabbit Polyclonal antibody against IL6R. Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL6R, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL6R, the complex of IL-6 and IL6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892). Soluble form of IL6R has been found in human serum and urine.

Target Interleukin 6 Receptor (IL6R)
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human IL6R.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P08887 (UniProt, ExPASy)
UniProt Secondary AC A8KAE8, B2R6V4, Q16202, Q53EQ7, Q5FWG2, Q5VZ23
UniProt Entry Name IL6RA_HUMAN
Gene Symbol IL6R
GeneID 3570
KEGG hsa:3570
String 9606.ENSP00000357470
Molecular Weight Calculated MW: 40 kDa, 51 kDa
Observed MW: 47 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Interleukin 6 Receptor (IL6R) Antibody

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