Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody is a Rabbit Polyclonal antibody against Insulin Like Growth Factor 1 Receptor (IGF1R). Insulin Like Growth Factor 1 Receptor (IGF1R), also named as CD221, belongs to the protein kinase superfamily, Tyr protein kinase family and Insulin receptor subfamily. Insulin Like Growth Factor 1 Receptor (IGF1R) binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, Insulin Like Growth Factor 1 Receptor (IGF1R) binds IGF1. The hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, the hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Long and hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. Defects in Insulin Like Growth Factor 1 Receptor (IGF1R) may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance). The antibody is specific to Insulin Like Growth Factor 1 Receptor (IGF1R).

Target	Insulin Like Growth Factor 1 Receptor (IGF1R)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1201-1367 of human IGF1R.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08069 (UniProt, ExPASy)
UniProt Secondary AC	B1B5Y2, Q14CV2, Q9UCC0
UniProt Entry Name	IGF1R_HUMAN
Gene Symbol	IGF1R
GeneID	3480
NCBI Accession	NP_000866.1
KEGG	hsa:3480
String	9606.ENSP00000268035
Molecular Weight	Calculated MW: 155 kDa Observed MW: 100 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Insulin Like Growth Factor 1 Receptor (IGF1R)

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