Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) Antibody

Insulin Like Growth Factor Binding Protein 3 (IGFBP3) is a member of the insulin-like growth factor binding protein (IGFBP) family with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.

Target	Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 163-193 amino acids from the N-terminal region of human IGFBP3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P17936 (UniProt, ExPASy)
UniProt Secondary AC	A4D2F5, D3DVM0, Q2V509, Q6P1M6, Q9UCL4
UniProt Entry Name	IBP3_HUMAN
NCBI Accession	NP_000589.2 NP_001013416.1
KEGG	hsa:3486
String	9606.ENSP00000370473
Molecular Weight	Calculated MW: 31.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat IGFBP3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3)

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