INSR (pY1150) / IGF1R (pY1135) Antibody

Catalogue No: abx000129
Price: £120.00
(Size: 20 µl)
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INSR (pY1150) / IGF1R (pY1135) Antibody is a Rabbit Polyclonal antibody against INSR (pY1150) / IGF1R (pY1135). Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation.

Target INSR (pY1150) / IGF1R (pY1135)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y1189 of human Insulin Receptor beta.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P06213 (UniProt, ExPASy)
UniProt Secondary AC Q17RW0, Q59H98, Q9UCB7, Q9UCB8, Q9UCB9
UniProt Entry Name INSR_HUMAN
Gene Symbol INSR, IGF1R
GeneID 3643
KEGG hsa:3643
String 9606.ENSP00000303830
Molecular Weight Calculated MW: 154 kDa, 155 kDa, 156 kDa
Observed MW: 80 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on INSR (pY1150) / IGF1R (pY1135)

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