Integrin Alpha M / CD11b (ITGAM) Antibody

Integrin alpha M (ITGAM) Antibody is a Rabbit Polyclonal antibody against Integrin alpha M (ITGAM). Integrin alpha M (ITGAM), also named as CD11B and CR3A, belongs to the integrin alpha chain family. It is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Integrin alpha M (ITGAM) is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. It is also a receptor for fibrinogen, factor X and ICAM1. Integrin alpha M (ITGAM) recognizes P1 and P2 peptides of fibrinogen gamma chain.

Target	Integrin Alpha M / CD11b (ITGAM)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 145-340 of CD11b/ITGAM.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P11215 (UniProt, ExPASy)
UniProt Secondary AC	Q4VAK0, Q4VAK1, Q4VAK2
UniProt Entry Name	ITAM_HUMAN
Gene Symbol	ITGAM
GeneID	3684
NCBI Accession	NP_000623.2
KEGG	hsa:3684
String	9606.ENSP00000441691
Molecular Weight	Calculated MW: 127 kDa Observed MW: 170 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Integrin Alpha M / CD11b (ITGAM)

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