Integrin Alpha M / CD11b (ITGAM) Antibody
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Catalogue No: abx025834
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Integrin alpha M (ITGAM) is the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.
Research Articles on Integrin Alpha M / CD11b (ITGAM)
| Target | Integrin Alpha M / CD11b (ITGAM) |
| Research Area | Cellular Differentiation and Adhesion, Tumor Immunity, Infection Immunity, Immunology, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500, IHC-P: 1/25, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 253-282 amino acids from the N-terminal region of human CD11b. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P11215 (UniProt, ExPASy) |
| UniProt Secondary AC | Q4VAK0, Q4VAK1, Q4VAK2 |
| UniProt Entry Name | ITAM_HUMAN |
| KEGG | hsa:3684 |
| String | 9606.ENSP00000441691 |
| Molecular Weight | Calculated MW: 127 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |