Ionomycin

Ionomycin is a small molecule from Streptomyces conglobatus which can act as a Ca2+ ionophore. It is provided as a colorless wax. (Note: vial may appear empty.)

In Human neutrophils, Ionomycin can induce a rise in cytosolic Ca 2+ from cytosolic Ca2+ stores and Ca2+ influx . It can activate and prime 2 mM and 20-200 nM Neutrophil NADPH Oxidase, respectively. It can also downregulate beta-catenin/TCF signaling in a colon cancer cell line by suppressing TCF binding to it's DNA-binding site. In Rat hepa-toma cells, sub-lethal Ionomycin cam initiate the stress response by activating SAPK/JNK and HSF/HSE, leading to upregulation of HSP70 biosynthesis.

This product acts on the following target types: Ionophore, Antibiotic.
This product acts on the following biochemical pathways: Calcium signaling, JNK pathway, Apoptosis inducer.
This product may be of interest in the following research areas and diseases: Cellular stress, Infectious disease, Cell death.

Please note that our chemical products are for scientific research use only in a laboratory and are not for medical or veterinary use. This product can only be dispatched to a scientific business or laboratory address.

Target	Ionomycin
Research Area	Cellular Stress, Infectious Disease, Cell Death
Form	Solid
Purity	> 99% (TLC: 20% CH3OH in Ethyl Acetate). Conforms to structure by NMR.
Reconstitution	Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 30 mg/ml).
Storage	Store desiccated at -20°C. Solutions can be stored at -20°C for up to 2 months.
Shelf Life	Up to 24 months.
Molecular Weight	709.0 g/mol
Molecular Formula	C41H72O9
Buffer	Not applicable.
CAS Number	56092-81-0
Availability	Shipped within 5-10 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on Ionomycin

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