Insulin Gene Enhancer Protein ISL-1 (ISL1) Antibody

ISL1 (ISL1 transcription factor, LIM/homeodomain) is a member of the LIM/homeodomain family of transcription factors.It binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression.It is central to the development of pancreatic cell lineages and may also be required for motor neuron generation.Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry.Mutations in this gene have been associated with maturity-onset diabetes of the young.

Target	Insulin Gene Enhancer Protein ISL-1 (ISL1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human ISL1 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P61371 (UniProt, ExPASy)
UniProt Secondary AC	P20663, P47894
UniProt Entry Name	ISL1_HUMAN
Gene Symbol	ISL1
GeneID	3670
OMIM	600366
HGNC	6132
KEGG	hsa:3670
Ensembl	ENSG00000016082
String	9606.ENSP00000230658
Molecular Weight	39 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Insulin Gene Enhancer Protein ISL-1 (ISL1)

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