Integrin Alpha IIb / CD41 (ITGA2B) Antibody

ITGA2B encodes integrin alpha chain 2b.Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation.Mutations that interfere with this role result in thrombasthenia.In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Target	Integrin Alpha IIb / CD41 (ITGA2B)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08514 (UniProt, ExPASy)
UniProt Secondary AC	B2RCY8, O95366, Q14443, Q17R67
UniProt Entry Name	ITA2B_HUMAN
Gene Symbol	ITGA2B
GeneID	3674
OMIM	187800
HGNC	6138
KEGG	hsa:3674
Ensembl	ENSG00000005961
String	9606.ENSP00000262407
Molecular Weight	113.4 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Integrin Alpha IIb / CD41 (ITGA2B)

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