Integrin Alpha 5 (ITGA5) Antibody

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha 5 beta 1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc gamma R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.

Target	Integrin Alpha 5 (ITGA5)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human ITGA5 expressed in E. coli.
Isotype	IgG2a
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08648 (UniProt, ExPASy)
UniProt Secondary AC	Q96HA5
UniProt Entry Name	ITA5_HUMAN
Gene Symbol	ITGA5
GeneID	3678
OMIM	135620
HGNC	6141
KEGG	hsa:3678
Ensembl	ENSG00000161638
String	9606.ENSP00000293379
Molecular Weight	114 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Integrin Alpha 5 (ITGA5)

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