Integrin Alpha 5 (ITGA5) Antibody
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Catalogue No: abx011678
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US$427.75
(Size: 100 µl)
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Datasheet SDS
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha 5 beta 1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc gamma R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.
Research Articles on Integrin Alpha 5 (ITGA5)
| Target | Integrin Alpha 5 (ITGA5) |
| Research Area | Cellular Differentiation and Adhesion |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human ITGA5 expressed in E. coli. |
| Isotype | IgG2a |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P08648 (UniProt, ExPASy) |
| UniProt Secondary AC | Q96HA5 |
| UniProt Entry Name | ITA5_HUMAN |
| Gene Symbol | ITGA5 |
| GeneID | 3678 |
| OMIM | 135620 |
| HGNC | 6141 |
| KEGG | hsa:3678 |
| Ensembl | ENSG00000161638 |
| String | 9606.ENSP00000293379 |
| Molecular Weight | 114 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |