Integrin Alpha-L (ITGAL) Antibody

ITGAL Antibody is a Rabbit Polyclonal antibody against ITGAL. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.

Target	Integrin Alpha-L (ITGAL)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500, IHC-P: 1/50 - 1/100, IF/ICC: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 26-340 of human CD11a/LFA-1A/ITGAL.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P20701 (UniProt, ExPASy)
UniProt Secondary AC	O43746, Q45H73, Q96HB1, Q9UBC8
UniProt Entry Name	ITAL_HUMAN
Gene Symbol	ITGAL
GeneID	3683
NCBI Accession	NP_001107852.1
KEGG	hsa:3683
String	9606.ENSP00000349252
Molecular Weight	Calculated MW: 129 kDa Observed MW: 180 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Integrin Alpha-L (ITGAL)

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